T lenfositlerin Th1 ve Th17 alt gruba değişimini ve monosit aktivasyonunu indükler, IFNγ üretimini uyarır.

Serum Th1/Th2 Cytokines in Primary Sjögren’s Syndrome
Objectives: Cytokines are thought to play an important role in the pathogenesis of primary Sjögren’s syndrome (pSS) by promoting cellular and humoral autoimmune processes. The role of key Th1 and Th2 cytokines in pSS have been reported, but their mixed or polarized effect is still a matter of debate. Here we sought to identify clinically significant Th1/Th2 cytokines in serum of pSS patients.
Methods: Serum samples were collected from a cohort of well-characterized pSS patients and healthy controls. The levels of 29 serum analytes, containing both Th1 and Th2 cytokines, chemokines and growth factors were measured in duplicate using a multiplexed bead-based flow cytometric assay. Mean cytokine levels between groups were compared and correlations between the levels of significant cytokines and clinical and laboratory variables were examined.
Results: Of the 29 analytes tested, levels of 15 (e.g. IL-1α, IL-1β, IL-2, IL-8, IL-10, IL-12p40, IL-12p70, IL-13, IL-15, IFN-γ, TNF-α, IP-10, MIP-1α, TGF-α and GM-CSF) were significantly elevated in pSS patients compared to controls and included largely Th1 cytokines. The levels of most of these cytokines were correlated negatively with unstimulated whole saliva flow and tear flow determined by Schirmer’s test, but positively with the focus scores of labial salivary gland biopsy and serological titers of anti-Ro/SSA autoantibody.
Conclusions: Our results suggest that a Th1 pattern of immune response characteristic of cellular immunity is predominant in pSS.